The journey from Pensacola to Tampa covers approximately 650 kilometers. The most efficient route is via I-10 East to I-75 South. Expect a driving time of about 6.5 hours. This is a popular route for travelers heading to the Gulf Coast of Central Florida. Driving is the most practical and common way to make this trip.
Total Distance: 650 km driving distance; 550 km straight-line air distance.
Traffic can be heavy near the Tampa metro area during rush hour.
Spring and autumn offer the most comfortable weather for exploring Tampa's attractions.