The trip from Perrysburg to Cincinnati is approximately 300 km, taking about 3 hours by car via I-75 S. This is a major north-south route that connects the two cities directly. Driving is the most practical mode of transport. The route is well-maintained and passes through several major cities, including Dayton.
Total Distance: Driving distance 300 km, straight-line air distance 270 km.
I-75 can be very busy; check traffic reports before leaving.
Any time of year, though avoid peak traffic hours in Dayton and Cincinnati.