The drive from Placerville to Fresno is a 150-mile trip south through the heart of the Central Valley. You will take CA-49 to CA-99. This route is the gateway to Yosemite and the southern Sierra Nevada.
Total Distance: Driving distance 240 km; Air distance 200 km.
CA-99 can be busy with agricultural trucks; drive carefully.
Spring for blooming orchards or Fall for harvest season.