The trip from Pleasanton to Santa Clara is a 35-mile journey west across the Dumbarton Bridge. You will primarily use I-680 South to CA-84 West. Expect a travel time of 50 to 70 minutes depending on traffic. This route is a common commute for residents in the Tri-Valley area working in Silicon Valley.
Total Distance: 55 km driving distance, 45 km air distance.
The Dumbarton Bridge has a toll; use a FasTrak transponder for convenience.
Any time, though avoid peak morning and evening commute hours.