The trip from Pleasanton to Vacaville is a 50-mile journey north through the East Bay. You will primarily use I-680 North to I-80 East. Expect a travel time of 60 to 85 minutes depending on traffic. This route is a common commute for residents in the Tri-Valley area working in the East Bay.
Total Distance: 80 km driving distance, 70 km air distance.
The Benicia-Martinez Bridge has a toll; use a FasTrak transponder for convenience.
Any time, though avoid peak morning and evening commute hours.