The distance from Pomona to Las Vegas is about 380 kilometers. Driving via I-15 North is the most direct route, taking 4 to 6 hours depending on traffic. Alternatively, you can fly from nearby airports. Las Vegas is famous for its casinos, shows, and nightlife. This is a very popular route for weekend getaways.
Total Distance: Driving distance 380 km, straight-line air distance 350 km.
I-15 can be very congested on Friday afternoons and Sunday evenings.
Anytime, but avoid peak holiday weekends.