The drive from Ponca City to Las Vegas is approximately 1,300 miles west. You will take US-60 to I-40 west across the Texas Panhandle, New Mexico, and Arizona, then US-93 north to Las Vegas. This is a very long drive. Expect a significant change in landscape from plains to desert.
Total Distance: Driving distance 2,100 km; Air distance 1,700 km.
The drive through the desert is scenic.
Fall or Spring to avoid the extreme summer heat.