The drive from Ponca City to San Francisco is approximately 1,800 miles west. You will take US-60 to I-40 west across the Texas Panhandle, New Mexico, Arizona, and into California, then I-5 north to San Francisco. This is a very long drive. Expect a significant change in landscape from plains to desert to mountains.
Total Distance: Driving distance 2,900 km; Air distance 2,400 km.
The drive through the desert is scenic.
Fall or Spring to avoid the extreme summer heat.