The drive from Port St. Lucie to Jacksonville is approximately 350 kilometers, taking about 3 hours and 30 minutes via I-95 North. Jacksonville is a large coastal city known for its beaches, parks, and cultural attractions. It is a major destination for tourists and business travelers.
Total Distance: Driving distance 350 km; straight-line air distance 320 km.
I-95 can be very busy; check traffic before you leave.
Spring and fall for pleasant weather and outdoor activities.