Driving
Port St. Lucie to Key West
Updated: 28 May 2026
The drive from Port St. Lucie to Key West takes you down the Florida coast and through the Florida Keys, covering about 250 miles. The most common route is via the Florida Turnpike to US-1 South, which provides a scenic path through the islands. Expect a travel time of approximately 6 hours depending on traffic. Key West is known for its historic sites, vibrant nightlife, and beautiful sunsets.
Total Distance: 400 km driving distance; 350 km straight-line air distance.
Fastest Way
Driving is the only practical method, taking about 6 hours.
Cheapest Way
Driving your own car is the most cost-effective way to travel.
Compare Port St. Lucie to Key West Routes
Driving
Direct
Duration
6 hours
Avg Price
$40-$60 in fuel
Operator
N/A
Route
Florida Turnpike to US-1 South.
US-1 South is a scenic but slow route; plan accordingly.
Travel Tips
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DrivingUS-1 South is a scenic but slow route; plan accordingly.
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ParkingParking in Key West can be difficult; use public parking lots.
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DiningExplore the diverse culinary scene in downtown Key West.
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WeatherBe prepared for hot, humid summers.
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SafetyStay aware of your surroundings in crowded areas.
Safety Tips
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Pedestrian SafetyUse crosswalks and obey traffic signals.
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Night SafetyStick to well-lit areas when walking at night.
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EmergencyDial 911 for any emergency assistance.
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BelongingsKeep your bag secure in crowded tourist areas.
People Also Ask
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Is there a train to Key West?No, there is no passenger rail service to Key West.
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How long is the drive?Expect about 6 hours of driving time.
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Are there tolls?Yes, there are tolls on the Florida Turnpike.
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Is Key West walkable?The downtown area is walkable, but a car is needed for the drive.
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What is the best time to visit?Spring and Fall offer the best weather for sightseeing.
Quick Info
- From Port St. Lucie, Florida, United States
- To Key West, Florida, United States
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Modes
Best Time to Travel
Spring and Fall for mild weather and fewer crowds.
Things to Do in Key West
1
Ernest Hemingway Home and Museum
A historic home and museum dedicated to the famous author.
2
Mallory Square
A popular square known for its sunset celebrations.
3
Duval Street
A famous street lined with bars, restaurants, and shops.
4
Key West Lighthouse
A historic lighthouse offering panoramic views.
Tags
Port St. Lucie to Key West
driving to Key West
Florida travel guide
PSL to Key West commute
Key West island travel
Florida cross-state travel
Key West attractions
driving across Florida
