The trip from Portland, Maine to Rochester, New York is a 400-mile drive west. You will take I-95 South, I-495, and then I-90 West (the Massachusetts Turnpike) into New York, eventually connecting to I-490. The drive typically takes about 7 hours. This route is a major path for travel across the Northeast.
Total Distance: Driving distance 640 km, straight-line air distance 520 km.
The Massachusetts Turnpike and New York Thruway are toll roads.
Spring and fall are ideal for the pleasant weather and scenic views.