Flight
Driving
Portsmouth to Saint Louis
Updated: 28 May 2026
The drive from Portsmouth to St. Louis covers 1,500 kilometers and takes about 15 hours. You will follow I-64 West for almost the entire journey, making it a very straightforward route. Alternatively, you can fly from Norfolk to St. Louis Lambert International Airport (STL) with a connection.
Total Distance: 1,500 km driving, 1,300 km air distance.
Fastest Way
Flying is the fastest, saving about 10 hours of travel time.
Cheapest Way
Driving is the most cost-effective option for this distance.
Compare Portsmouth to Saint Louis Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 5 hours | 15 hours |
| Avg Price | $300-$500 | $200-$300 in fuel |
| Operator | American Airlines | Personal Vehicle |
| Route | ORF to STL via CLT or ORD. | I-64 W. |
| Tip | Connecting flights are the only option. | I-64 is a direct shot from Virginia to Missouri. |
Travel Tips
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TrafficAvoid the I-64/I-70 interchange in St. Louis during rush hour.
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DiningTry St. Louis-style pizza and toasted ravioli.
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NavigationUse GPS to navigate the city's highway loops.
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Rest StopsLouisville, KY is a great place to stop for a meal.
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ParkingUse the parking garages near the Arch for easy access.
Safety Tips
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Road ConditionsBe aware of construction on I-64 in Illinois.
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Night DrivingStay on major highways at night.
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EmergencyKeep a roadside emergency kit in your car.
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WeatherBe prepared for humidity in the summer.
People Also Ask
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Is there a direct flight?No, you will need to connect through a hub.
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How long is the drive?Expect 15 hours of driving time.
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What is the best route?I-64 West is the most direct path.
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Are there tolls?There are no major tolls on this specific route.
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Is St. Louis walkable?Downtown is walkable, but you will need a car for other areas.
Quick Info
- From Portsmouth, Virginia, United States
- To Saint Louis, Missouri, United States
-
Modes
Best Time to Travel
April to June or September to October for mild weather.
Things to Do in Saint Louis
1
Gateway Arch
The iconic symbol of St. Louis. Take the tram to the top for incredible views.
2
Forest Park
One of the largest urban parks in the US. It houses the zoo and art museum.
3
City Museum
A unique, interactive museum built from reclaimed materials. It is fun for all ages.
4
Anheuser-Busch Brewery
Take a tour of the historic brewery and learn about beer history.
Tags
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