The drive from Prairieville to Memphis is 400 miles and takes about 6 hours. You will head north on I-10 to I-12, then take I-55 North all the way to Memphis. This route passes through Jackson, Mississippi, and follows the Mississippi River corridor. It is a relatively flat and straightforward drive. Expect moderate traffic as you enter the Memphis metropolitan area.
Total Distance: 645 km driving distance; 560 km straight-line air distance.
I-55 is the most direct route and is well-maintained.
Spring and fall offer the most comfortable temperatures for sightseeing.