Is there a train to Des Moines?

No, there is currently no passenger rail service to Des Moines.

How long is the drive?

The drive takes approximately 4 hours.

What is the best highway?

I-35 South is the primary and most efficient highway.

No, there are no tolls on this route.

Yes, it is a standard interstate route with high safety ratings.

Prior Lake

Des Moines

Driving

Prior Lake to Des Moines

Updated: 29 May 2026

The journey from Prior Lake to Des Moines covers approximately 245 miles primarily via I-35 South. You will traverse the rolling farmlands of southern Minnesota and central Iowa. The drive typically takes 4 hours under normal traffic conditions. This route is a major corridor for Midwestern commerce and travel. Expect to pass through Albert Lea and Ames before reaching the capital city.

Total Distance: 395 km driving distance; 350 km straight-line air distance.

Fastest Way

Driving via I-35 South is the fastest route, taking exactly 4 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method for this distance.

Compare Prior Lake to Des Moines Routes

Driving

Direct

Duration

4 hours

Avg Price

$40-$60 in fuel

Operator

Personal Vehicle

Route

MN-13 South to I-35 South through Albert Lea and Ames.

Check road conditions on 511MN before departing during winter months.

Travel Tips

Fuel Stops
Fill up in Albert Lea, Minnesota, as gas prices are often lower there than in the Twin Cities metro.
Traffic Alerts
Use the Iowa 511 app to monitor construction zones near the I-35 and I-80 interchange.
Rest Areas
Utilize the well-maintained rest areas along I-35 in southern Minnesota for safe breaks.
Dining
Stop in Ames for a variety of college-town dining options located just off the interstate.
Timing
Avoid leaving Prior Lake during Friday afternoon rush hour to bypass congestion on I-35W.

Safety Tips

Winter Driving
Carry an emergency kit with blankets and salt if traveling between November and March.
Wildlife
Be alert for deer crossing the highway, especially during dawn and dusk hours in rural Iowa.
Speed Limits
Observe strict speed limit enforcement in small towns along the route where limits drop suddenly.
Fatigue
Take a 15-minute break every two hours to maintain alertness on the monotonous stretches of I-35.