The drive from Rancho Cucamonga to Modesto is approximately 350 miles, taking about 5.5 hours via I-5 North. This route takes you through the heart of the Central Valley. Modesto is known for its agricultural roots, being the inspiration for the movie American Graffiti, and its proximity to Yosemite National Park.
Total Distance: 563 km driving distance; 490 km straight-line air distance.
I-5 is a straightforward drive but can be very hot in the summer.
April to May or September to October for pleasant weather.