The journey from Rochester to Memphis covers about 700 miles. Driving is the most practical choice, taking about 10 hours via I-75 and I-55. This route takes you through the heart of the Midwest and into the South. It is a straightforward drive that is perfect for a long weekend getaway.
Total Distance: 1,100 km driving, 950 km air distance.
Stop in Nashville for a break and a meal.
April to June or September to October for the most comfortable weather.