The drive from Royal Oak to Cincinnati is a direct 420 km route down I-75 South. You will pass through Toledo and Dayton before arriving in Cincinnati. The route is a major interstate corridor, making it very straightforward. Expect a travel time of about 4 hours, though traffic near Cincinnati can be heavy during peak hours.
Total Distance: 420 km driving, 370 km air distance.
I-75 is a very busy highway; stay alert for sudden traffic slowdowns.
Spring or autumn for pleasant weather to explore the city's hills and riverfront.