Driving
Sanford to Key West
Updated: 28 May 2026
The drive from Sanford to Key West covers approximately 650 km and takes about 7 to 8 hours depending on traffic. You will take the Florida Turnpike south to Miami, then merge onto US-1, the Overseas Highway. This route is famous for the Seven Mile Bridge and stunning ocean views. Be prepared for heavy traffic in the Miami area and on the single-lane sections of the Keys.
Total Distance: Driving distance 650 km; straight-line air distance 550 km.
Fastest Way
Driving, taking roughly 7.5 hours with minimal stops.
Cheapest Way
Driving your own vehicle, costing primarily in fuel and tolls.
Compare Sanford to Key West Routes
Driving
Direct
Duration
7 hours 30 mins
Avg Price
$80 - $150 (fuel + tolls)
Operator
Personal Vehicle
Route
Florida Turnpike to US-1
Use a SunPass for tolls to save time and money on the Turnpike.
Travel Tips
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TrafficAvoid driving through Miami during rush hour.
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ParkingParking in Key West is limited and expensive; use public lots.
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Speed LimitsStrictly observe speed limits in the Keys; they are heavily enforced.
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HydrationKeep water in your car for the long drive.
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StopsStop in Islamorada for fresh seafood.
Safety Tips
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Road ConditionsUS-1 is a two-lane road; be patient with slow-moving traffic.
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FatigueTake breaks every 2 hours to stay alert.
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WeatherWatch for sudden tropical rain showers.
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EmergencyDial 911 for roadside assistance.
People Also Ask
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How long is the drive?Approximately 7 to 8 hours.
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Are there tolls?Yes, on the Florida Turnpike.
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Is it a scenic drive?Yes, the Overseas Highway is world-famous.
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Can I take a bus?Yes, but it is much slower than driving.
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What is the best time to leave?Early morning to avoid Miami traffic.
Quick Info
- From Sanford, Florida, United States
- To Key West, Florida, United States
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Modes
Best Time to Travel
March to May for pleasant weather and fewer crowds.
Things to Do in Key West
1
Ernest Hemingway Home
Visit the historic home of the famous author and see the six-toed cats.
2
Mallory Square
Famous for the nightly sunset celebration with street performers.
3
Duval Street
The heart of Key West nightlife, filled with bars and restaurants.
4
Dry Tortugas National Park
Accessible by ferry, this park features a massive historic fort.
Tags
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