Is there a direct flight?

No, most flights from Santa Ana to Memphis require a layover.

How long is the drive?

The drive takes approximately 28 hours of pure driving time.

What is the best highway?

Interstate 40 is the primary route for this cross-country trip.

Amtrak does not offer a direct route from Santa Ana to Memphis.

What is the cheapest month?

January and February typically offer the lowest airfares.

Santa Ana

Memphis

Flight Driving

Santa Ana to Memphis

Updated: 30 May 2026

The journey from Santa Ana to Memphis spans approximately 2,900 kilometers across the American Southwest. Flying from John Wayne Airport (SNA) to Memphis International Airport (MEM) is the most efficient method, typically involving a connection in Dallas or Phoenix. Driving requires traversing I-40 East, a major artery passing through Arizona, New Mexico, and Oklahoma. Expect diverse landscapes ranging from coastal plains to high deserts and the Mississippi River delta. This route is best navigated by air for speed or by car for a multi-day scenic adventure.

Total Distance: 2,900 km driving distance; 2,550 km straight-line air distance.

Fastest Way

Flying from John Wayne Airport (SNA) takes approximately 6 hours total.

Cheapest Way

Driving is generally cheaper for groups of three or more people.

Compare Santa Ana to Memphis Routes

	Flight Connecting	Driving Direct
Duration	6 hours	28 hours
Avg Price	$350 - $600	$400 - $600 in fuel
Operator	American Airlines	Personal Vehicle
Route	SNA to MEM via DFW or PHX.	I-15 N to I-40 E.
Tip	Book at least three weeks in advance to secure lower fares.	Ensure your vehicle is serviced for high-heat desert driving.

Travel Tips

Airport Choice
Use SNA instead of LAX to avoid heavy traffic and long security lines.
Hydration
If driving, carry extra water when crossing the Mojave Desert.
Time Zones
Be prepared to adjust your watch as you cross from Pacific to Central Time.
Fuel Stops
Fill up in major cities to avoid higher prices in remote desert stations.
Accommodation
Book hotels in Memphis near the downtown area for better access to attractions.

Safety Tips

Desert Safety
Check your cooling system before driving through Arizona and New Mexico.
Night Driving
Avoid driving through remote desert stretches at night due to wildlife.
Emergency Kit
Keep a basic tool kit and first aid supplies in your vehicle.
Weather Awareness
Monitor weather reports for potential dust storms in the Southwest.