The drive from Santa Cruz to Reno is approximately 250 miles, taking you over the Sierra Nevada mountains. You will typically take Highway 17 to I-80 East, passing through Sacramento and the Donner Pass. The journey takes about 4 hours and 30 minutes, though winter weather can significantly impact travel times. This route connects the coastal redwoods to the high desert of Northern Nevada.
Total Distance: 400 km driving, 320 km air distance.
Check Caltrans road conditions for the Donner Pass before departing during winter.
Late spring to early fall to avoid snow closures on the Donner Pass.