The drive from Santa Fe to Waco is approximately 250 kilometers. You will take I-45 North to TX-6 North for the entire duration of the trip. The drive typically takes 3 hours. This route takes you through rural areas and is a common commute for those working in the area. It is a straightforward drive.
Total Distance: 250 km driving distance; 220 km straight-line air distance.
Expect heavy traffic in the Houston area.
Mid-day to avoid rush hour traffic.