The drive from Sewanee to Baton Rouge is approximately 450 miles. You will take I-24 to I-65, then I-10 to reach the city. The trip takes about 6.5 hours. You will pass through Birmingham and Mobile, Alabama. This is a direct and efficient route.
Total Distance: 725 km driving distance; 600 km straight-line air distance.
Stop in Mobile for a break.
Spring or Autumn for pleasant weather.