The drive from Sewanee to Charleston covers 480 miles through Tennessee, Georgia, and South Carolina. You will take I-24 to I-26, which leads directly to the coast. The trip takes approximately 7.5 hours. You will pass through the scenic foothills of the Blue Ridge Mountains. It is a popular route for those visiting the historic Lowcountry.
Total Distance: 775 km driving distance; 600 km straight-line air distance.
Stop in Columbia, SC for a lunch break.
Spring or Autumn for pleasant weather and lower humidity.