The drive from Sewanee to Columbus takes you south through Georgia. You will take I-24 East to I-75 South, then I-85 South. The total distance is approximately 220 miles. Expect a drive time of about 3.5 hours. This route is well-traveled and straightforward.
Total Distance: 350 km driving distance, 280 km air distance.
Traffic in Atlanta can be heavy.
Spring for the beautiful city parks.