The drive from Sewanee to Miami takes you south through Georgia and Florida. You will take I-24 East to I-75 South, then Florida's Turnpike. The total distance is approximately 850 miles. Expect a drive time of about 13 hours. This route is well-traveled and straightforward.
Total Distance: 1370 km driving distance, 1100 km air distance.
Traffic in Atlanta and Miami can be heavy.
Winter for the pleasant weather.