The drive from Sewanee to New Orleans is approximately 480 miles. You will take I-24 to I-65, then I-10 to reach the city. The trip takes about 7 hours. You will pass through Birmingham and Mobile, Alabama. This is a classic Southern road trip.
Total Distance: 770 km driving distance; 650 km straight-line air distance.
Stop in Mobile for a seafood lunch.
Spring or Autumn for pleasant weather and festivals.