The drive from Sewanee to Orlando takes you south through Georgia and Florida. You will take I-24 East to I-75 South, then Florida's Turnpike. The total distance is approximately 600 miles. Expect a drive time of about 9 hours. This route is well-traveled and straightforward.
Total Distance: 960 km driving distance, 780 km air distance.
Traffic in Atlanta and Orlando can be heavy.
Spring or Fall for comfortable weather.