The drive from Sisters to Salem is a scenic 180-kilometer journey across the Cascade Mountains. You will typically take US-20 West to OR-22 West. The drive takes about 3 hours depending on the route and mountain pass conditions. This journey transitions from the high desert to the lush, green Willamette Valley. Be prepared for winding mountain roads and potential weather changes, especially in winter.
Total Distance: 180 km driving distance; 130 km straight-line air distance.
Check ODOT road reports for mountain pass conditions before leaving.
Late spring to early fall for the best road conditions over the mountain passes.