The drive from South Boston to Indianapolis covers about 600 miles. You will head west through West Virginia and Ohio before reaching Indiana. The journey takes approximately 9 to 10 hours via I-64 and I-65. Indianapolis is known for its racing history and vibrant downtown. Expect mountainous terrain in West Virginia.
Total Distance: 965 km driving, 800 km air distance.
Be prepared for mountain driving in West Virginia.
May to October for pleasant weather.