Flight
Driving
South Boston to Saint Louis
Updated: 28 May 2026
The journey from South Boston to St. Louis is best made by driving via I-64, which takes about 12 to 13 hours. Alternatively, you can fly from Raleigh-Durham International Airport (RDU) to St. Louis Lambert International Airport (STL). St. Louis is known for the Gateway Arch, its rich history, and vibrant culture. Be prepared for heavy traffic in the city.
Total Distance: 1,300 km driving distance; 1,100 km straight-line air distance.
Fastest Way
Flying from RDU is the fastest way to reach St. Louis.
Cheapest Way
Driving is cheaper for groups, but flying is much faster.
Compare South Boston to Saint Louis Routes
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Connecting from RDU
|
Direct
|
|
|---|---|---|
| Duration | 2 hours 30 mins | 12 hours 30 mins |
| Avg Price | $200-$400 | $140-$200 in fuel |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | RDU to STL. | I-64 West. |
| Tip | Book flights well in advance for the best prices. | Plan for an overnight stop to avoid fatigue. |
Travel Tips
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TransportationA car is recommended for getting around St. Louis.
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DiningTry the local St. Louis-style pizza and toasted ravioli.
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TrafficSt. Louis traffic can be heavy; plan your travel accordingly.
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WeatherBe prepared for hot summers and cold winters.
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WalkingSome areas are walkable, but a car is generally needed.
Safety Tips
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General SafetyStay in well-lit, populated areas.
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Vehicle SafetyNever leave valuables in your car.
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EmergencyDial 911 for any emergency.
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AwarenessBe aware of your surroundings in crowded tourist areas.
People Also Ask
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Is it better to fly or drive?Flying is much faster for this distance.
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How long is the drive?The drive is approximately 12.5 hours.
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What is the best airport?St. Louis Lambert International Airport (STL) is the main hub.
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Are there tolls?No major tolls on this route.
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Is St. Louis safe?Yes, tourist areas are generally safe, but remain aware of your surroundings.
Quick Info
- From South Boston, Virginia, United States
- To Saint Louis, Missouri, United States
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Modes
Best Time to Travel
April to June or September to October for mild weather.
Things to Do in Saint Louis
1
Gateway Arch
Visit the iconic monument and take a tram to the top for incredible views.
2
Forest Park
Explore one of the largest urban parks in the country, featuring a zoo and museums.
3
St. Louis Zoo
Visit one of the best zoos in the country, located in Forest Park.
4
City Museum
Experience a unique, interactive museum built from repurposed materials.
Tags
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