The journey from South Daytona to Charleston covers approximately 480 kilometers primarily via Interstate 95 North. You will traverse through the coastal plains of Georgia before entering the Lowcountry of South Carolina. Driving is the most practical method, typically taking 5 hours depending on traffic near Jacksonville. The route offers scenic views of the Atlantic coastline and historic southern towns. Expect to pay tolls on specific Florida turnpike segments if you choose that route instead of I-95.
Total Distance: 480 km driving distance; 420 km straight-line air distance.
Avoid rush hour traffic in Jacksonville to save 45 minutes.
Spring months of March to May for mild temperatures and blooming azaleas.