The journey from South Pasadena to Fort Myers is approximately 180 kilometers along the Gulf Coast. You will primarily use I-75 South. The drive takes about 2 hours depending on traffic. This is a popular route for residents of the Tampa Bay area visiting the beautiful beaches and attractions of Fort Myers.
Total Distance: 180 km driving, 160 km air distance.
I-75 is the fastest and most direct route.
Anytime, but avoid the peak tourist season in winter.