The route from St. George to Cheyenne is an 850-kilometer drive. You will take I-15 North to I-80 East, passing through Salt Lake City and across the high plains of Wyoming. This drive takes approximately 8 hours of active transit. It is a straightforward route that is manageable in a single day. You will experience the transition from the desert to the high-altitude plains of Wyoming.
Total Distance: 850 km driving distance; 650 km straight-line air distance.
I-80 can be very windy; keep both hands on the wheel.
Summer months to avoid snow on the high-altitude passes of I-80.