How long is the drive?

The drive takes approximately 4 hours.

Is it better to take a bus?

Driving is usually more convenient.

What is the best route?

I-35 South is the primary route.

Yes, tourist areas are generally safe and well-patrolled.

St Joseph

Des Moines

Driving

St Joseph to Des Moines

Updated: 28 May 2026

The drive from St. Joseph to Des Moines is a 250-mile journey that takes approximately 4 hours. You will typically head south on I-35, passing through the Twin Cities and across the state of Iowa. This is a common travel route for those moving between the two states.

Total Distance: 400 km driving distance, 370 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking about 4 hours.

Cheapest Way

Driving is the most cost-effective way to travel between these two cities.

Compare St Joseph to Des Moines Routes

Driving

Direct

Duration

4 hours

Avg Price

$35-$50 in fuel

Operator

Personal Vehicle

Route

I-35 South.

Traffic in the Twin Cities can be heavy; avoid rush hours.

Travel Tips

Traffic
Traffic in the Twin Cities can be heavy; avoid peak hours.
Parking
Parking in Des Moines is available in garages and on the street.
Weather
Iowa winters can be harsh; be prepared for snow and ice.
Events
Check for local events in Des Moines before you go.
Navigation
Use a GPS to navigate the Twin Cities area.

Safety Tips

Winter Driving
Iowa winters can be severe; keep an ice scraper and blanket in your car.
Speed Limits
Observe speed limits strictly on the highway.
Vehicle Check
Check your tire pressure and oil levels before leaving.
Emergency Kit
Keep a basic emergency kit in your trunk.