St Joseph
St Joseph
Des Moines
Des Moines
Driving

St Joseph to Des Moines

Updated: 28 May 2026

The drive from St. Joseph to Des Moines is a 250-mile journey that takes approximately 4 hours. You will typically head south on I-35, passing through the Twin Cities and across the state of Iowa. This is a common travel route for those moving between the two states.

Total Distance: 400 km driving distance, 370 km straight-line air distance.
Fastest Way
Driving is the fastest method, taking about 4 hours.
Cheapest Way
Driving is the most cost-effective way to travel between these two cities.
Compare St Joseph to Des Moines Routes
Driving
Direct
Duration
4 hours
Avg Price
$35-$50 in fuel
Operator
Personal Vehicle
Route
I-35 South.

Traffic in the Twin Cities can be heavy; avoid rush hours.

Travel Tips
  • Traffic
    Traffic in the Twin Cities can be heavy; avoid peak hours.
  • Parking
    Parking in Des Moines is available in garages and on the street.
  • Weather
    Iowa winters can be harsh; be prepared for snow and ice.
  • Events
    Check for local events in Des Moines before you go.
  • Navigation
    Use a GPS to navigate the Twin Cities area.
Safety Tips
  • Winter Driving
    Iowa winters can be severe; keep an ice scraper and blanket in your car.
  • Speed Limits
    Observe speed limits strictly on the highway.
  • Vehicle Check
    Check your tire pressure and oil levels before leaving.
  • Emergency Kit
    Keep a basic emergency kit in your trunk.
People Also Ask
  • How long is the drive?
    The drive takes approximately 4 hours.
  • Is it better to take a bus?
    Driving is usually more convenient.
  • Are there tolls?
    The route is toll-free.
  • What is the best route?
    I-35 South is the primary route.
  • Is Des Moines safe?
    Yes, tourist areas are generally safe and well-patrolled.
Quick Info
  • From St Joseph, Minnesota, United States
  • To Des Moines, Iowa, United States
  • Modes
Best Time to Travel

Any time of year, but be prepared for winter snow.

Things to Do in Des Moines
1
Iowa State Capitol
Tour the historic capitol building, which features a beautiful gold dome.
2
Des Moines Art Center
Discover the contemporary art exhibits.
3
Greater Des Moines Botanical Garden
Visit the beautiful garden and conservatory.
4
Pappajohn Sculpture Park
Explore the outdoor sculpture park in the heart of the city.
Tags
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