How long is the drive?

The drive takes approximately 9 hours.

Is it better to take a bus?

Driving is usually more convenient.

What is the best route?

I-35 and I-70 are the primary routes.

Yes, tourist areas are generally safe and well-patrolled.

St Joseph

St. Louis

Driving

St Joseph to St. Louis

Updated: 28 May 2026

The drive from St. Joseph to St. Louis is a 600-mile journey that takes approximately 9 hours. You will typically head south on I-35 and then east on I-70, passing through the Twin Cities and across the states of Iowa and Missouri. This is a common travel route for those moving between the two states.

Total Distance: 960 km driving distance, 850 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking about 9 hours.

Cheapest Way

Driving is the most cost-effective way to travel between these two cities.

Compare St Joseph to St. Louis Routes

Driving

Direct

Duration

9 hours

Avg Price

$90-$120 in fuel

Operator

Personal Vehicle

Route

I-35 S to I-70 E.

Traffic in the Twin Cities and St. Louis can be heavy; avoid rush hours.

Travel Tips

Traffic
Traffic in the Twin Cities and St. Louis can be heavy; avoid peak hours.
Parking
Parking in St. Louis is available in garages and on the street.
Weather
Missouri winters can be harsh; be prepared for snow and ice.
Events
Check for local events in St. Louis before you go.
Navigation
Use a GPS to navigate the Twin Cities and St. Louis areas.

Safety Tips

Winter Driving
Missouri winters can be severe; keep an ice scraper and blanket in your car.
Speed Limits
Observe speed limits strictly on the highway.
Vehicle Check
Check your tire pressure and oil levels before leaving.
Emergency Kit
Keep a basic emergency kit in your trunk.