The drive from Surfside Beach to Greenville covers 230 miles, taking you from the coast to the Upstate region of South Carolina. The most direct route is via I-20 West and I-26 West, which takes about 4 hours. You will pass through Columbia and the rolling hills of the Piedmont. This route is popular for those visiting the scenic Blue Ridge foothills. Greenville is known for its vibrant downtown and beautiful Falls Park on the Reedy.
Total Distance: 370 km driving distance; 330 km straight-line air distance.
I-26 can be busy near Spartanburg; plan for extra time.
Autumn is spectacular in the Upstate as the leaves change color in the nearby mountains.