The journey from Tampa to Key West is one of the most iconic road trips in the United States, covering roughly 700 kilometers. You will head south on I-75 toward Miami, then transition to the Overseas Highway (US-1). The final stretch involves driving across 42 bridges, including the famous Seven Mile Bridge. This route offers stunning views of the Gulf of Mexico and the Atlantic Ocean. Expect a total travel time of 8 to 9 hours depending on traffic in the Miami area.
Total Distance: 700 km driving distance; 480 km straight-line air distance.
Leave Tampa before 5 AM to avoid heavy Miami morning traffic.
March to May for pleasant weather and fewer crowds than the winter peak.