No, there is no passenger train service to Key West.

How long is the drive?

The drive is approximately 8 hours.

What is the best way to get around?

A car is essential for exploring the area.

Is the Hemingway Home worth it?

Yes, it is a fascinating historical site.

What is the weather like?

Key West has a warm, tropical climate year-round.

Tarpon Springs

Key West

Driving

Tarpon Springs to Key West

Updated: 01 Jun 2026

The journey from Tarpon Springs to Key West is approximately 650 kilometers. Driving via I-75 South and US-1 is the most practical and efficient method. Expect a drive time of about 8 hours depending on traffic.

Total Distance: 650 km driving, 550 km air.

Fastest Way

Driving takes 8 hours.

Cheapest Way

Driving is the only practical option.

Compare Tarpon Springs to Key West Routes

Driving

Direct

Duration

8 hours

Avg Price

$100 - $150 in fuel

Operator

Personal Vehicle

Route

I-75 S to US-1 S

Expect heavy traffic in the Florida Keys.

Travel Tips

Navigation
Use a GPS to navigate the Florida Keys.
Dining
Try the local seafood and key lime pie.
Parking
Parking in Key West can be expensive; check hotel rates.
Booking
No booking required for driving.
Weather
Key West has a tropical climate; pack light clothing.

Safety Tips

Urban Safety
Stay in well-lit areas when walking downtown at night.
Vehicle Security
Lock your car and remove all valuables when parking.
Public Transit
The Duval Loop is generally safe, but be aware of your surroundings.
Emergency Info
Keep local emergency numbers saved in your phone.