The distance from Tarpon Springs to San Diego is approximately 2,400 miles. Flying from Tampa International Airport (TPA) to San Diego International Airport (SAN) is the most practical method, taking about 5.5 hours in the air. Driving is a massive 38 to 40-hour journey. Flying is highly recommended for this cross-country trip.
Total Distance: 3,900 km driving distance; 3,500 km straight-line air distance.
Book well in advance for the best fares.
Spring and Autumn are the most pleasant times to visit San Diego.