The drive from Troy to Louisville is approximately 450 km. You will head east toward St. Louis and then take I-64 East all the way to Louisville. This route is very straightforward and takes you through the heart of Illinois and Indiana. Driving is the most practical mode of transport for this trip. Expect a travel time of about 4.5 hours, depending on traffic in the St. Louis and Louisville metro areas.
Total Distance: 450 km driving, 420 km air distance.
I-64 is a major artery; expect some construction delays.
May for the Kentucky Derby or October for pleasant autumn weather.