The journey from Uniontown to Buffalo is a 350-kilometer trip. You can drive via I-79 North, which typically takes about 4 hours. This is a straightforward route that takes you through the heart of Western Pennsylvania and into New York.
Total Distance: 350 km driving, 300 km air distance.
The route is simple and well-marked.
Any season is suitable, but summer is great for exploring Buffalo's waterfront.