The journey from Van Alstyne to San Francisco is approximately 2,800 kilometers. You will take US-75 South to I-40 West, then merge onto I-5 North all the way to San Francisco. This route typically takes 26 to 28 hours. It is a long but direct drive through Texas, New Mexico, Arizona, and California.
Total Distance: 2,800 km driving distance; 2,400 km straight-line air distance.
Expect heavy traffic near the San Francisco city limits.
Travel mid-week to avoid weekend traffic on I-5.