Driving
Waterloo to Keokuk
Updated: 31 May 2026
The drive from Waterloo to Keokuk is approximately 200 miles and takes 3 hours and 30 minutes. You will follow US-218 South for the entire journey, passing through Cedar Rapids, Iowa City, and Mount Pleasant. This is a major highway route that is well-maintained and efficient. Keokuk is located at the southernmost tip of Iowa, right on the Mississippi River. It is a long but straightforward drive through the heart of the state.
Total Distance: 320 km driving distance; 270 km straight-line air distance.
Fastest Way
Driving via US-218 South is the fastest method, taking 3 hours 30 minutes.
Cheapest Way
Driving your own vehicle is the most economical option, costing about 35 dollars in fuel.
Compare Waterloo to Keokuk Routes
Driving
Direct
Duration
3 hours 30 minutes
Avg Price
30-40 USD
Operator
Personal Vehicle
Route
US-218 South through Cedar Rapids and Iowa City.
US-218 is a major highway; watch for heavy traffic near cities.
Travel Tips
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TrafficExpect delays in Iowa City during university events.
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NavigationUS-218 is well-marked, but stay alert for highway splits.
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DiningIowa City is a great place to stop for lunch on the way.
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ParkingKeokuk has plenty of parking near the riverfront.
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Road ConditionsCheck for construction on US-218 before you leave.
Safety Tips
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SpeedingPolice monitor speeds on US-218 near small towns.
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WeatherFog can be an issue near the river in the mornings.
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VisibilityKeep your headlights on during the day for safety.
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EmergencyKeep a basic emergency kit in your car.
People Also Ask
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Is Keokuk on the river?Yes, it is located on the Mississippi River.
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How long is the drive?The drive takes about 3 hours and 30 minutes.
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Are there tolls?No, there are no tolls on this route.
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What is the best route?US-218 South is the direct route.
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Is there a train?No, there is no passenger rail service.
Quick Info
- From Waterloo, Iowa, United States
- To Keokuk, Iowa, United States
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Modes
Best Time to Travel
Summer and early autumn for the best weather and river views.
Things to Do in Keokuk
1
Keokuk Riverfront
Enjoy the scenic views of the Mississippi River and the historic lock and dam.
2
George M. Verity Riverboat Museum
Visit this historic riverboat museum to learn about the Mississippi River's steamboat era.
3
Rand Park
Explore this beautiful park known for its scenic views and annual events.
4
Keokuk National Cemetery
Visit this historic cemetery, the first national cemetery established in the United States.
Tags
Waterloo to Keokuk
US-218 South
Keokuk travel
driving to Keokuk
Waterloo to Keokuk route
Iowa road trip
fastest way to Keokuk
Keokuk commute
