Driving
Waynesboro to Key West
Updated: 28 May 2026
The drive from Waynesboro to Key West is a long trip down the East Coast and through the Florida Keys. You will take I-64 E to I-95 S, then head south on US-1. The trip covers approximately 1,800 km and takes about 18 hours. This route is a major artery for vacationers.
Total Distance: Driving distance 1,800 km, Air distance 1,500 km.
Fastest Way
Driving is the fastest option as there are no direct flights from local airports.
Cheapest Way
Driving is the most economical way to reach Key West from Waynesboro.
Compare Waynesboro to Key West Routes
Driving
Direct
Duration
18 hours
Avg Price
$220 - $300 in fuel
Operator
Personal Vehicle
Route
I-64 E to I-95 S to US-1 S.
Expect heavy traffic on US-1 through the Florida Keys.
Travel Tips
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TrafficExpect heavy traffic on US-1 in the Florida Keys.
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ParkingUse the parking garages in Key West for easy access.
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FoodTry the local Key lime pie.
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WalkingThe island is very walkable.
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EventsCheck the schedule for events at the Key West Convention Center.
Safety Tips
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Highway SafetyStay alert for construction zones on US-1.
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Night DrivingAvoid long stretches of night driving if you are fatigued.
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EmergencyKeep an emergency kit in your car for long-distance travel.
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General SafetyStick to well-lit areas when walking downtown at night.
People Also Ask
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Is the drive safe?Yes, the route is well-traveled and safe.
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Are there tolls?Some parts of the route may have tolls, check your GPS.
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What is the best route?I-95 S to US-1 S is the most direct route.
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Is Key West walkable?The island is very walkable.
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What is the best time to visit?Winter and spring offer the best weather for outdoor activities.
Quick Info
- From Waynesboro, Virginia, United States
- To Key West, Florida, United States
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Modes
Best Time to Travel
Winter or Spring for pleasant weather.
Things to Do in Key West
1
Duval Street
Experience the famous nightlife, restaurants, and shops.
2
Ernest Hemingway Home and Museum
Tour the historic home of the famous author.
3
Key West Lighthouse
Climb the lighthouse for panoramic views of the island.
4
Mallory Square
Watch the famous sunset celebration.
Tags
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