The drive from Waynesboro to Louisville is a relatively quick and scenic trip across the Appalachian Mountains. You will take I-64 W for the entire journey, passing through West Virginia and into Kentucky. The trip covers approximately 750 km and takes about 7.5 hours. This route is very straightforward.
Total Distance: Driving distance 750 km, Air distance 600 km.
Be prepared for winding roads through the mountains of West Virginia.
Spring or Fall for pleasant weather.