Is there a bus to Houston?

Yes, Greyhound offers service from St. Louis to Houston with transfers.

How long is the drive?

The drive is approximately 13 hours.

What is the best route?

I-55 South to I-45 South is the most direct path.

Yes, there are direct flights from St. Louis (STL) to Houston (IAH/HOU).

Houston is generally safe, but like any large city, stay aware of your surroundings.

Wentzville

Houston

Driving

Wentzville to Houston

Updated: 28 May 2026

The drive from Wentzville to Houston is a long-haul journey covering 900 miles. You will head south through Missouri, Arkansas, and Louisiana before entering Texas. The primary route involves taking I-55 South to I-40, then I-49 and I-45 South. Expect a driving time of approximately 13 hours. This route takes you through diverse landscapes, from the Ozarks to the Gulf Coast plains.

Total Distance: 1,448 km driving distance; 1,250 km straight-line air distance.

Fastest Way

Driving via I-55 and I-45 is the fastest route, taking 13 hours.

Cheapest Way

Driving your own vehicle is the most economical choice at roughly $140 in fuel.

Compare Wentzville to Houston Routes

Driving

Direct

Duration

13 hours

Avg Price

$130-$190

Operator

Personal Vehicle

Route

I-55 S to I-40 W, then I-49 S and I-45 S through Shreveport.

Houston traffic is intense; plan to arrive outside of peak rush hours.

Travel Tips

Traffic
Houston's highway system is complex; use a reliable navigation app to avoid major congestion.
Rest Stops
Shreveport, Louisiana, is a great place to stop for a meal and a break halfway through the trip.
Weather
Houston is prone to heavy rain; be prepared for sudden downpours while driving.
Parking
Downtown Houston parking can be pricey; look for public lots or hotel parking deals.
Navigation
Download offline maps as you will be passing through some rural areas in Arkansas and Louisiana.

Safety Tips

Fatigue
This is a very long drive; consider an overnight stop in Shreveport to stay safe.
Vehicle Check
Check your tires and cooling system, as the heat and distance are demanding on vehicles.
Emergency Kit
Carry extra water and a first-aid kit, as some stretches of I-49 are quite remote.
Speeding
Louisiana and Texas state police are very active on the interstates; watch your speed.