Is there a bus to Miami?

Yes, Greyhound offers service from St. Louis to Miami with transfers.

How long is the drive?

The drive is approximately 20 hours.

What is the best route?

I-64 East to I-75 South is the most direct path.

Yes, there are direct flights from St. Louis (STL) to Miami (MIA).

Miami is generally safe, but stick to well-lit, populated areas in the tourist districts.

Wentzville

Miami

Driving

Wentzville to Miami

Updated: 28 May 2026

The drive from Wentzville to Miami is a massive 1,350-mile journey. You will head south through Kentucky, Tennessee, Georgia, and the entire length of Florida. The primary route involves taking I-64 East to I-75 South, then connecting to the Florida Turnpike. Expect a driving time of approximately 20 hours. This is a long-distance trip that requires careful planning and multiple overnight stops.

Total Distance: 2,172 km driving distance; 1,850 km straight-line air distance.

Fastest Way

Driving via I-64 and I-75 is the fastest route, taking 20 hours.

Cheapest Way

Driving your own vehicle is the most economical choice at roughly $220 in fuel.

Compare Wentzville to Miami Routes

Driving

Direct

Duration

20 hours

Avg Price

$200-$300

Operator

Personal Vehicle

Route

I-64 E to I-75 S, then Florida Turnpike S to Miami.

The Florida Turnpike is a toll road; ensure you have a SunPass or toll-by-plate account.

Travel Tips

Traffic
Miami traffic is very heavy; plan your travel to avoid peak rush hours.
Rest Stops
Atlanta and Orlando are good places to stop, but consider staying in suburbs to avoid downtown traffic.
Weather
Miami is hot and humid; stay hydrated and wear sunscreen.
Tolls
Florida has many toll roads; consider getting a SunPass for easier travel.
Navigation
Use a GPS with real-time traffic updates to navigate the complex highway systems in major cities.

Safety Tips

Fatigue
This is a very long drive; plan for at least two overnight stops to stay safe.
Vehicle Check
Check your tires and cooling system, as the heat and distance are demanding on vehicles.
Emergency Kit
Carry extra water and a first-aid kit, as some stretches of I-75 are quite remote.
Speeding
Georgia and Florida state police are very active on the interstates; watch your speed.