Is there a bus to Orlando?

Yes, Greyhound offers service from St. Louis to Orlando with transfers.

How long is the drive?

The drive is approximately 17 hours.

What is the best route?

I-64 East to I-75 South is the most direct path.

Yes, there are direct flights from St. Louis (STL) to Orlando (MCO).

Orlando is generally safe, but stick to well-lit, populated areas in the tourist districts.

Wentzville

Orlando

Driving

Wentzville to Orlando

Updated: 28 May 2026

The drive from Wentzville to Orlando is a major cross-country trek covering 1,100 miles. You will head south and east through Kentucky, Tennessee, and Georgia before entering Florida. The primary route involves taking I-64 East to I-75 South. Expect a driving time of approximately 17 hours. This is a popular route for families heading to the theme parks, so plan for multiple overnight stops.

Total Distance: 1,770 km driving distance; 1,500 km straight-line air distance.

Fastest Way

Driving via I-64 and I-75 is the fastest route, taking 17 hours.

Cheapest Way

Driving your own vehicle is the most economical choice at roughly $180 in fuel.

Compare Wentzville to Orlando Routes

Driving

Direct

Duration

17 hours

Avg Price

$160-$240

Operator

Personal Vehicle

Route

I-64 E to I-75 S through Nashville, Atlanta, and Gainesville.

Atlanta traffic is a major bottleneck; try to pass through at night or mid-day.

Travel Tips

Traffic
Atlanta and Orlando traffic can be very heavy; plan your arrival times carefully.
Rest Stops
Atlanta, Georgia, is a good place to stop, but consider staying in a suburb to avoid downtown traffic.
Weather
Florida is hot and humid; stay hydrated and wear sunscreen.
Tolls
Florida has many toll roads; consider getting a SunPass for easier travel.
Navigation
Use a GPS with real-time traffic updates to navigate the complex highway systems in major cities.

Safety Tips

Fatigue
This is a very long drive; plan for at least one overnight stop to stay safe.
Vehicle Check
Check your tires and cooling system, as the heat and distance are demanding on vehicles.
Emergency Kit
Carry extra water and a first-aid kit, as some stretches of I-75 are quite remote.
Speeding
Georgia and Florida state police are very active on the interstates; watch your speed.