The trip from Woodland, Pennsylvania to Buffalo, New York is a 3.5-hour drive. You will take I-80 West to I-219 North, which leads directly into Buffalo. This route is efficient and takes you through the scenic landscape of Western Pennsylvania and New York. There are no practical flight options for this distance, making driving the only viable choice.
Total Distance: 320 km driving distance; 280 km straight-line air distance.
I-219 is a major route; expect some traffic near Buffalo.
May to October for clear roads and pleasant weather.