Is there a train to Knoxville?

No, there is no direct Amtrak service to Knoxville, Tennessee.

How long is the drive?

The drive takes about 8.5 hours.

The downtown and tourist areas are generally safe.

What is the best way to get around?

A car is recommended for exploring the city.

Is the Sunsphere worth it?

Yes, it is an iconic landmark with great views.

Alexandria

Knoxville

Driving

Alexandria to Knoxville

Updated: 28 May 2026

The journey from Alexandria to Knoxville covers approximately 500 miles. Driving via I-66 West and I-81 South is the most direct route, taking about 8 to 9 hours. Knoxville is the gateway to the Great Smoky Mountains and home to the University of Tennessee.

Total Distance: 800 km driving distance, 650 km straight-line air distance.

Fastest Way

Driving from Alexandria to Knoxville is the fastest, taking about 8.5 hours.

Cheapest Way

Driving is the most cost-effective for groups.

Compare Alexandria to Knoxville Routes

Driving

Direct

Duration

8 hours 30 mins

Avg Price

$90-$140 in fuel

Operator

Personal Vehicle

Route

I-66 West to I-81 South.

Expect heavy truck traffic on I-81.

Travel Tips

Traffic
Avoid the I-40/I-75 interchange in Knoxville during rush hour.
Parking
Use the parking garages in downtown Knoxville for easy access to attractions.
Dining
Try the local restaurants in the Old City neighborhood.
Transport
A car is recommended for exploring the city and surrounding areas.
Booking
Book hotels in the downtown area for the best access to major attractions.

Safety Tips

Driving
Be alert for heavy truck traffic on the I-81 corridor.
Urban Safety
Stay in well-lit areas when walking downtown at night.
Emergency Prep
Keep a basic emergency kit in your car.
Weather
Check for winter storm warnings if traveling between November and March.